Valproic Acid-Induced Changes of 4D Nuclear Morphology in Astrocyte Cells
نویسندگان
چکیده
منابع مشابه
Valproic acid induced hyperammonaemic encephalopathy.
OBJECTIVE To observe clinical and laboratory features of valproic acid-induced hyperammonaemic encephalopathy in patients taking valproic acid. METHODS Observational study was conducted at the Neurology Department, Dow University of Health Sciences, Civil Hospital, Karachi, from February 26, 2010 to March 20, 2011. Ten patients on valproic acid therapy of any age group with idiopathic or seco...
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Histone deacetylase inhibitors such as valproic acid (VPA) are promising anticancer agents that change the acetylation status of histones and loosen the chromatin structure. We assessed nuclear structure changes induced by VPA in prostate cancer LNCaP, CWR22R, DU145, and PC3 cell lines and xenografts and their potential use as a biomarker of treatment. In vitro tissue microarrays consisted of p...
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Ribeirão Preto School of Medicine, University of São Paulo, São Paulo SP, Brazil: Physician Resident in Neurology, Department of Neurosciences and Behaviour Sciences; Neurologist and Associated Professor, Department of Neurosciences and Behaviour Sciences; Emergencist Physician, Departament of Internal Medicine. Idiosyncratic reactions to drugs are adverse effects not straightly related with ph...
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Background: b-Thalassemia is a common autosomal recessive disorder in human caused by a defect in b-globin chain synthesis. The most common mutations causing b-Thalassemia have been found to be splicing mutations. Most of which activate aberrant cryptic splicing/sites without complete disruption of normal splicing. IVSI-110 mutation, a common splicing mutation, leads to a 90% reduction of norma...
متن کاملRibonucleic acid-induced changes in mammalian cells.
Previous experiments have shown that under proper conditions ribonucleic acid (RNA) can indeed initiate differentiation." 2 Of particular interest in this work is the development of highly specific structure. That the type of structure developed correlates with the tissue source of RNA indicates a response of the reacting tissue to a message carried directly by RNA or RNA-containing substances ...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2021
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e20-08-0502